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What Is 4-AcO-DET? 4-AcO-DET, also known as 4-acetoxy-det is a psychedelic compound of the tryptamine family, being first developed by Albert Hoffman in 1952.

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4-AcO-DET, also known as 4-acetoxy-det is a psychedelic compound of the tryptamine family, being first developed by Albert Hoffman in 1952. It is a somewhat obscure tryptamine that has been growing in popularity with the research community due to its psychoactive effects that closely resemble those of psilocybin. It is the acetylated version of 4-HO-DET and the higher homolog of the more popular 4-AcO-DET and 4-ACO-MET.

Also known as ethacetin and ethylacybin, 4-AcO-DET has been used as a replacement for psilocybin mushrooms in individuals who experience digestion problems when ingesting the mushrooms for religious practices or ceremonies. This being said, it is not approved for human consumption, and its toxicity profile is not known.

Chemical Properties Of 4-AcO-DET

Chemical Formula: C16H22N2O2

Full Name: 4-Acetoxy-N, N-diethyltryptamine

Molecular Weight: 274.36 g/mol

Purity: >98%

As with all tryptamines, 4-AcO-DET has a core structure consisting of a bicyclic indole heterocycle attached at R3 to an amino group. It is an N-substituted diethyl homolog of psilocin (4-HO-DMT), with which it shares several chemical properties.

Although it is unclear exactly how this compound produces psychedelic effects in users it is believed to be a result of its ability to bind at the 5-HT2A receptor. Normally, the powerful neurotransmitter Serotonin would bind to this receptor. Because 4-AcO-DET is a partial agonist of the same receptors, it likely causes disruptions in the normal functioning of the serotonergic system.

What Are The Effects And Possible Warnings Of 4-AcO-DET

A member of the Tryptamine family, 4ACO-DET can be expected to have very similar tryptamine effects as other substances of the same class.

Sedation or Increased Energy: The effects of Tryptamines on humans have been studied in a great deal of depth since the start of the 20th century. Clinical research has shown that Tryptamines have the ability to both sedate or energize test subject depending upon the mood, environment, and overall disposition of the individual.

Tactile Sensations: One of the most commonly reported effects is that of tactile sensations. It is often described as a warm, vibrating feeling. This is particularly true for 4-AcO-DET which anecdotal evidence suggests is much more stimulating than other closely related tryptamines such as 4-AcO-DET.

Visual Hallucinations: One of the defining effects of psychedelic tryptamines is visual hallucinations and distortions. These effects most commonly manifest themselves as distortions in size and movement of objects as well as vivid hallucinations of geometric shapes.

Auditory Distortion And Hallucinations: All tryptamines have the possibility of inducing audio hallucinations and distortions in test subjects. Because little information exists, it is difficult to compare the auditory hallucinations caused by 4-AcO-DET to other similar compounds.

Euphoria: Many users report feelings of Euphoria and joy after ingestion, something which is quite common across the board with compounds of the tryptamine family.


Heart Palpitations: As previously stated, the overall health profile of 4-AcO-DET has not been studied in human subjects, and therefore little is known about its toxicity. This being said, there is always the possibility of cardiotoxicity, since all serotonin-based psychedelics exhibit some level of cardiotoxicity at certain doses.

Anxiety: All tryptamines have the potential to cause high levels of anxiety in test subjects.

Headaches: Some test subjects report headaches after ingesting psilocybin. Because 4-AcO-DET is structurally very similar to psilocybin, the possibility that some test subjects may experience headaches is high.

Note: Because minimal clinical research has been conducted, exact dosage levels are unknown and all available dosage information has been gathered via anecdotal reports. 4-AcO-DET is not approved for human consumption and is not to be handled without proper laboratory equipment including eye protection and gloves.

Where To Buy 4-AcO-DET.

Here, we offer high quality, laboratory-grade 4-AcO-DET. We are the premier option for those looking to buy research chemicals. Please note, you must be at least 18 years of age or older to purchase 4-AcO-DET from Chemicals shop. All research chemicals sold are for use in laboratory-based research and experimentation and not for human consumption.

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